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Propionic Acidemia
Propionic Acidemia is a rare
metabolic disorder characterized by deficiency of propionyl CoA carboxylase, an
enzyme involved in the breakdown (catabolism) of the chemical "building blocks"
(amino acids) of certain proteins. Symptoms most commonly become apparent during
the first weeks of life and may include abnormally diminished muscle tone
(hypotonia), poor feeding, vomiting, listlessness (lethargy), excessive loss of
fluids from bodily tissues (dehydration), and episodes of uncontrolled
electrical activity in the brain (seizures). Without appropriate treatment, coma
and potentially life-threatening complications may result. In rare cases, the
condition may become apparent later during infancy and may be associated with
less severe symptoms and findings. Propionic Acidemia is inherited as an
autosomal recessive trait
|
Remedy |
Characteristics
Symptoms |
Patient Worse by |
Patient Better by |
| Nux Vomica |
Rather thin, spare, quick, active, nervous, and
irritable Does a good deal of mental work; has mental strains and leads a
sedentary life, found in prolonged office work, overstudy, and close
application to business, with its cares and anxieties.
Seeks stimulants, coffee, wine, possibly in excess; or, again, he hopes
to quiet his excitement, by indulging in the sedative effects of tobacco, if
not really a victim, to the seductive drugs, like opium, etc
Takes preferably rich and stimulating food; wine and women play their
part to make him forget the close application of the day
Pre-eminently a male remedy
Irritable, nervous system, hypersensitive and over-impressionable
Convulsions, with consciousness; worse, touch, moving
Zealous fiery temperament
Easily chilled, avoid open air, etc
Always seems to be out of tune; inharmonious spasmodic action
Sour taste, and nausea in the morning, after eating
Sour, bitter eructations
Nausea and vomiting, with much retching
Desire for stimulants
Loves fats and tolerates them well
Difficult belching of gas
Wants to vomit, but cannot
Frequent ineffectual desire for stools, or passing but small
quantities at each attempt
Frequent calls to urinate; little and often
Easily excited desire
Menses too early, lasts too long; always irregular, blood
black with faint spells
Cannot sleep after 3 am until towards morning; awakes feeling
wretchedly
Drowsy after meals, and in early evening
Dreams full of bustle and hurry |
Morning Mental exertion
After eating
Touch
Spices
Stimulants
Narcotics
Dry weather
Cold |
From a nap, if allowed to finish it In evening
While at rest
In damp, wet weather
Strong pressure |
| Conium Maculatum |
Difficult gait, trembling, sudden loss of strength
while walking, painful stiffness of legs. etc Debility
General feeling as if bruised by blows
Great debility in the morning in bed
Weakness of body and mind, trembling, and palpitation
Terrible nausea, acrid heartburn and acid eructations; worse on
going to bed
Painful spasms of the stomach
Amelioration from eating and aggravation a few hours after meals; acidity
and burning; painful spot the level of the sternum
Tremulous weakness after every stool
Much difficulty in voiding; it flows and stops again
Sexual desire increased; power decreased
Menses delayed and scanty; parts sensitive |
Lying down Turning or rising in bed
Celibacy
Before and during menses
From taking cold
Bodily or mental exertion |
While fasting In the dark
From letting limbs hang down
Motion and pressure |
| Digitalis |
Pulse is weak, irregular, intermittent,
abnormally slow Slow pulse in recumbent posture, but irregular and
dicrotic on sitting up
Faint, as if dying
Bluish appearance of face
Prostration from slight exertion
Collapse
Sweet taste with constant ptyalism
Excessive nausea, not relieved by vomiting
Faintness, great weakness in stomach
Faintness and vomiting from motion
Discomfort, even after a small quantity of food, or from mere sight or
smell
Tenderness of epigastrium
Copious salivation
White, chalk-like, ashy, pasty stools
Nightly emission, with great weakness of genitals after coitus
Starts from sleep in alarm that he is falling from a height |
When sitting erect After meals and music |
When stomach is empty In open air |
| Ferrum Metallicum |
Best adapted to young weakly persons, anæmic and
chlorotic, with pseudo-plethora, who flush easily; cold extremities; over
sensitiveness; worse after any active effort Weakness from mere
speaking or walking though looking strong
Pallor of skin, mucous membranes, face, alternating with flushes
Orgasms of blood to face, chest, head, lungs, etc. Irregular distribution
of blood.
Muscles flabby and relaxed
Voracious appetite, or absolute loss of appetite
Loathing of sour things
Attempts to eat bring on diarrha
Spits up food by the mouthful
Eructations of food after eating, without nausea
Nausea and vomiting after eating
Vomiting immediately after eating
Vomiting after midnight
Intolerance of eggs
Distention and pressure in the stomach after eating
Heat and burning in stomach
Stool undigested, at night, while eating or drinking, painless
Urine involuntary; worse daytime
Menses remit a day or two, and then return; too early, too profuse,
last too long; pale, watery |
While sweating While sitting still
After cold washing and overheating
Midnight |
Walking slowly about After rising |
| Gelsemium |
General prostration Dizziness,
drowsiness, dullness, and trembling
Slow pulse, tired feeling, mental apathy
Muscular weakness
Complete relaxation and prostration. Lack of muscular co-ordination
General depression from heat of sun
Sensitive to a falling barometer; cold and dampness brings on many
complaints
Children fear falling, grab nurse or crib
Sluggish circulation
Putrid taste and breath
No thirst
Urine profuse, clear, watery, with chilliness and
tremulousness
Hysteric convulsions
Cannot get fully to sleep |
Damp weather Fog
Before a thunderstorm
Emotion, or excitement
Bad news
Tobacco-smoking
When thinking of his ailments
At 10 am |
Bending forward By profuse urination
Open air
Continued motion
Stimulants |
| Phosphorus |
Tall, slender persons, narrow chested, with thin,
transparent skin, weakened by loss of animal fluids, with great nervous
debility, emaciation, amative tendencies Great susceptibility to external
impressions, to light, sound, odors, touch, electrical changes,
thunder-storms
Suddenness of symptoms, sudden prostration, faints, sweats,
shooting pains, etc
Thirst for very cold water
Hunger soon after eating
Sour taste and sour eructations after every meal
Belching large quantities of wind, after eating
Throws up ingesta by the mouthfuls
Very fetid stools and flatus; long, narrow, hard, like a dog's;
difficult to expel
Desire for stool on lying on, left side
Great weakness after stool
Lack of power; irresistible desire; involuntary emissions, with
lascivious dreams
Menses too early and scanty-not profuse, but last too long
Leucorrha profuse, smarting, corrosive, instead of menses
Great drowsiness, especially after meals
Vivid dreams of fire; of hæmorrhage; lascivious dreams
Goes to sleep late and awakens weak
Short naps and frequent wakings |
Touch Physical or mental exertion
Twilight
Warm food or drink
Change of weather
From getting wet in hot weather
Evening
Lying on left or painful side
During a thunder-storm
Ascending stairs. |
In dark Lying on right side
Cold food
Cold
Open air
Washing with cold water
Sleep |
| Pulsatilla |
Pre-eminently a female remedy, especially for mild,
gentle, yielding disposition Sad, crying readily; weeps when talking;
changeable, contradictory
Seeks the open air; always feels better there, even though he is
chilly
Symptoms ever changing
Thirstless, peevish, and chilly
Great sensitiveness
Wants the head high; feels uncomfortable with only one pillow
Lies with hands above head
Greasy taste
Dry mouth, without thirst; wants it washed frequently; frequently
licks the dry lips
Offensive odor from mouth
Food, especially bread, tastes bitter
Much sweet saliva
Alternations of taste, bitter, bilious, greasy, salty, foul
Loss of taste
Desire for tonics
Averse to fat food, warm food, and drink
Eructations; taste of food remains a long time; after ices,
fruits, pasty
Bitter taste, diminished taste of all food
Flatulence
Dislikes butter
Heartburn
Thirstlessness
Vomiting of food eaten long before
Gnawing, hungry feeling
Water brash, with foul taste in the morning
No two stools alike
Two or three normal stools daily
Increased desire; worse when lying down
Tardy menses; too late, scanty, thick, dark, clotted, changeable,
intermittent
Leucorrha acrid, burning, creamy
Wide awake in the evening; first sleep restless
Wakes languid, unrefreshed
Irresistible sleepiness in afternoon |
From heat, rich fat food After eating
Towards evening
Warm room
Lying on left or on painless side
When allowing feet to hang down |
Open air Motion
Cold applications
Cold food and drinks, though not thirsty |
| Mercurius |
Tremors everywhere Weakness with
ebullitions and tremblings from least exertion
Complaints increase with the sweat and rest; all associated with a great
deal of weariness, prostration, and trembling
A human "thermometer"; sensitive to heat and cold
Breath, excretions and body smell foul
Tendency to formation of pus, which is thin, greenish, putrid; streaked
with thin blood
Sweetish metallic taste
Salivary secretions greatly increased; bloody and viscid
Saliva fetid, coppery
Great thirst, with moist mouth
Putrid eructations
Intense thirst for cold drinks
Urine dark, scanty, bloody, albuminous
Menses profuse, with abdominal pains
Leucorrha excoriating, greenish and bloody; sensation of rawness
in parts
General tendency to free perspiration, but patient is not relieved
thereby. |
At night Wet, damp weather
Lying on right side
Perspiring
Warm room and warm bed |
|
| Natrum Muriaticum |
Great debility; most weakness felt in the morning
in bed Coldness
Great liability to take cold
Dry mucous membranes
Constrictive sensation throughout the body
Great weakness and weariness
Oversensitive to all sorts of influences
Hungry, yet loose flesh
Heartburn, with palpitation
Unquenchable thirst
Sweats while eating
Craving for salt
Aversion to bread, to anything slimy, like oysters, fats
Has to wait a long time for it to pass if others are present
Menses irregular; usually profuse
Leucorrha acrid, watery
Sleepy in forenoon
Nervous jerking during sleep
Dreams of robbers |
Noise Music
Warm room
Lying down
About 10 a m
At seashore
Mental exertion
Consolation
Heat
Talking |
Open air Cold bathing
Going without regular meals
Lying on right side
Pressure against back
Tight clothing |
| Sepia |
Weakness, yellow complexion, bearing-down
sensation, especially in women, upon whose organism it has most pronounced
effect Upward tendency of its symptoms
Easy fainting
"Ball" sensation in inner parts
Acts best on brunettes
All pains are from below up.
Feels cold even in warm room
Taste salty, putrid
Everything tastes too salty
Nausea in morning before eating
Disposition to vomit after eating
Burning in pit of stomach
Longing for vinegar, acids, and pickles
Worse, after milk, especially when boiled
Acid dyspepsia with bloated abdomen, sour eructations
Loathes fat
Red, adhesive, sand in urine
Leucorrha yellow, greenish; with much itching |
Forenoons and evenings Washing
Laundry-work
Dampness
Left side
After sweat
Cold air
Before thunder-storm |
By exercise Pressure
Warmth of bed
Hot applications
Drawing limbs up
Cold bathing
After sleep |
| Aurum Metallicum |
Hopeless, despondent, and great desire to commit
suicide; every opportunity is sought for self-destruction Taste putrid
or bitter
Appetite and thirst increased, with qualmishness
Burning at stomach and hot eructations
Urine turbid, like buttermilk, with thick sediment
Sleepless; sobs aloud in sleep
Frightful dreams |
In cold weather When getting cold
Many complaints come on only in winter
From sunset to sunrise |
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| Baryta Carbonica |
Specially indicated in infancy and old age;
this remedy brings aid to scrofulous children, especially if they are
backward mentally and physically, are dwarfish, do not grow and develop,
have scrofulous ophthalmia, swollen abdomen, take cold easily, and then
always have swollen tonsil Very sensitive to cold
Offensive foot-sweats
very weak and weary, must sit or lie down or lean on something
Very averse to meeting strangers
Water brash, hiccough, and eructation, which relieves pressure as of a
stone
Hungry, but refuses food
Pain and weight immediately after a meal, with epigastric tenderness
Habitual colic, with hunger, but food is refused
Constipation, with hard, knotty stools
Diminished desire and premature impotence
Menses scanty
Talking in sleep; awakens frequently; feels too hot
Twitching during sleep |
While thinking of symptoms From washing
Lying on painful side
After warm food |
Walking in open air |
| Zincum Metallicum |
Defective vitality
Twitchings
Convulsions, with pale face and no heat.
Trembling, convulsive twitching and fidgety feet
Bloody taste
Hiccough, nausea, vomiting of bitter mucus
Burning in stomach, heartburn from sweet things
Cannot stand smallest quantity of wine
Ravenous hunger about 11 am
Great greediness when eating; cannot eat fast enough
Atonic dyspepsia, feeling as if stomach were collapsed
Griping after eating
Can only void urine when sitting bent backwards
Involuntary urination when walking, coughing or sneezing
Erections violent
Menses too late, suppressed; menses flow more at night
Cries out during sleep; body jerks; wakes frightened, stared
Nervous motion of feet when asleep
Loud screaming out at night in sleep without being aware of it |
At menstrual period From touch
Between 5 to 7 pm
After dinner
From wine |
While eating Discharges
Appearance of eruptions |
| Ruta |
All parts of the body are painful, as if bruised
Feeling of intense lassitude, weakness and despair
Gastralgia of aching, gnawing character
Constant urging to urinate, feels bladder full |
Lying down From cold, wet weather |
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